Disruption Of HER2–HER3 dimerization is very important for HER2-pushed signalling and it is targeted successfully by pertuzumab132. The optimistic effects from pertuzumab trials supported a strategy of focusing on HER3, which has a vital function in HER2-mediated tumorigenesis. HER3 is exclusive in comparison with other HER members of the family https://www.directivepublications.org/journal-of-clinical-breast-cancer/