Most cell entry by invading pathogens involves penetration of either the plasma membrane or the endo-lysosomal compartment to reach the cytosol. This process frequently inflicts membrane damage and provokes a cellular response. This Autophagic Punctum summarizes our recent study investigating how adenovirus endosome penetration is recognized and activates macroautophagy/autophagy. https://www.hindigyanvishv.com/flash-deal-Iowa-Cubs-Foam-Finger-p32059-hot-value/