ABSTRACT The structural and functional significance of somatic insertions and deletions in antibody chains is unclear. Here. we demonstrate that a naturally occurring three-amino-acid insertion within the influenza virus-specific human monoclonal antibody 2D1 heavy-chain variable region reconfigures the antibody-combining site and contributes to its high potency against the 1918 and 2... https://lampsusaes.shop/product-category/ceiling-fan-light-kit/